Imagine That You Are Investigating the Production of Insulin in Normal

Essay

Imagine that you are investigating the production of insulin in normal cells to help determine the cause of faulty insulin production in cells in which insulin appears to be synthesized but fails to be secreted from the cell. You design experiments using three different pharmaceutical compounds to help pinpoint the trouble spot in the protein synthetic pathway. The first compound blocks the movement of transport vesicles in the cytoplasm. The second blocks SRP release from the ribosome and mRNA. The third compound binds to and blocks the signal sequence so that the SRP cannot recognize it. For each of these three treatments, indicate (1) whether the protein would be made at all, and if so, (2) where in the cell you would find it.