If α-Synuclein Knock-Out Mice and Mice with Normal α-Synuclein Were

Multiple Choice

If α-synuclein knock-out mice and mice with normal α-synuclein were injected with α-synuclein in the substantia nigra, which mice would develop symptoms of Parkinson's disease and why?

A) The wild type mice would develop symptoms of Parkinson's as the α-synuclein would be able to cause mitochondrial dysfunction in the substantia nigra.
B) The α-synuclein knock-out mice would develop symptoms of Parkinson's as the α-synuclein would be able to cause mitochondrial dysfunction in the substantia nigra.
C) The α-synuclein knock-out mice would develop symptoms of Parkinson's because the α-synuclein protein would aggregate and spread cell to cell.
D) The α-synuclein wild type mice would develop symptoms of Parkinson's because the injected α-synuclein protein would recruit native α-synuclein and the aggregates could spread cell to cell.