Figure Q10-15 Illustrates the Data from One of the Original

Essay

Figure Q10-15 illustrates the data from one of the original experiments that showed evidence for 'silent synapses'. CA3 axons were stimulated while the postsynaptic response when the CA1 neuron were voltage-clamped at -65 mV. Figure Q10-15
A. Why were the CA1 neurons held at -65 mV?
B. What happened when the CA3 axons were stimulated before pairing, in which the presynaptic CA3 neurons were stimulated while the CA1 neurons were depolarized and what are two reasons for the result?
C. What happened when the CA3 axons were stimulated after 'pairing' and what was the interpretation of the result?
D. Summarize the idea of 'silent synapses' as a form of synaptic plasticity. Include the basic conclusions drawn from the experiments outlined in this and the previous experiment.