Essay
Leptin inhibits AgRP neurons and excites POMC neurons. AgRP neurons release GABA and neuropeptide Y (NPY) on POMC neurons in the arcuate nucleus (Figure Q8-35). 
Figure Q8-35
A. Describe the basic idea of an experiment that would show that agouti-related protein (AgRP) neurons are (1) necessary and (2) sufficient for food intake.
B. What are the two major ways that the AgRP neurons inhibit the activity and actions of the POMC neurons?
C. Based on the circuitry shown above, how does leptin inhibit eating?
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