Essay
The semaphorins are highly conserved axon guidance ligands with critical roles in nervous system development in both mammals and insects. It was recently reported that Sema1A can also function as a transmembrane receptor in reverse signaling to mediate photoreceptor axon-axon attraction in the developing Drosophila visual system. What kind of experimental result would be used to support a role in reverse signaling in the visual system?
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