Short Answer
Fill in each of the blanks with the best word or phrase selected from the list below. Not all words or phrases will be used; each word or phrase should be used only once.
The axon growth cone contains two prominent actin structures: _____________ are composed of bundled F-actin, whereas _____________ are a meshwork of branched F-actin. Many axon guidance cues affect the actin cytoskeleton through their receptors and downstream effectors such as the _____________ Rho, Rac, and Cdc42. These molecules are activated by _____________ and inactivated by _____________. For example, in the context of ephrin-A to EphA _____________ signaling, a GEF called ephexin was shown to mediate growth cone _____________ by linking the EphA receptor to RhoA.
collapse guanine nucleotide exchange factors (GEFs)
filopodia lamellipodia
forward reverse
G-protein-coupled receptors (GPCRs) small GTPases
GTPase activating proteins (GAPs) stabilization
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