Deck 9: Erythrocyte Metabolism and Membrane Structure and Function

Question 1

What is the normal life span of a red cell in circulation?

A)2 weeks
B)90 days
C)120 days
D)6 months

Answer 1

120 days

Question 2

What important function does 2,3-BPG perform?

A)maintains iron in the hemoglobin molecule in the ferrous state
B)prevents oxidative injury to the red cell
C)facilitates the delivery of oxygen to tissue
D)aids in the exchange of membrane lipids with lipids in plasma

Answer 2

facilitates the delivery of oxygen to tissue

Question 3

What is the fate of erythrocytes when anaerobic metabolic enzymes are reduced in concentration or absent?

A)destruction by the liver
B)destruction by monocytes in the blood
C)hemolysis
D)destruction by complement

Answer 3

hemolysis

Question 4

Why is the mature erythrocyte unable to synthesize proteins or lipids?

A)It has no nucleus.
B)It has no ribonucleic acid (RNA).
C)It cannot generate adenosine triphosphate (ATP).
D)Carrying oxygen interferes with synthesis.

Question 5

Select the metabolic pathway that converts toxic hydrogen peroxide produced by oxidant drugs to water:

A)Embden-Meyerhof pathway (EMP)
B)2,3-biphosphoglycerate (2,3-BPG)
C)methemoglobin reductase reaction
D)hexose monophosphate pathway

Question 6

Glucose-6-phosphate dehydrogenase (G6PD)is

A)an extremely rare enzyme deficiency.
B)necessary to maintain reduced glutathione in the mature red cell.
C)important for the production of ATP in the mature red cell.
D)important for the transport of carbon dioxide by the mature red cell.

Question 7

Which of the following is the metabolic pathway that generates a net gain of two molecules of ATP for erythrocyte energy needs?

A)EMP
B)2,3-BPG
C)methemoglobin reductase reaction
D)hexose monophosphate pathway

Question 8

What is responsible for erythrocyte deformability and maintaining cell shape?

A)membrane proteins
B)Na+ and K+ pump
C)membrane lipids
D)Ca2+ pump

Question 9

Which of the following is most responsible for the strength and pliancy of the red cell membrane?

A)glycophorin A
B)spectrin
C)cholesterol
D)ankyrin

Question 10

Which of the following erythrocyte activities requires energy?

A)oxygen delivery
B)carbon dioxide exchange
C)glucose transport into the RBC
D)protecting proteins from oxidative damage

Question 11

Which of the following is the metabolic pathway that regulates oxygen delivery to tissues?

A)EMP
B)2,3-BPG
C)methemoglobin reductase reaction
D)hexose monophosphate pathway

Question 12

What components of the erythrocyte membrane are responsible for its negative charge and are also blood group antigens?

A)peripheral proteins
B)cholesterol
C)cation pumps
D)transmembrane proteins

Question 13

The principle energy source for mature red blood cells (RBCs)is

A)the Krebs cycle.
B)the hexose monophosphate pathway.
C)ATP generated from anaerobic glycolysis.
D)adenosine diphosphate (ADP) generated from aerobic glycolysis.