Deck 21: Cytomegalovirus

Question 1

Individuals with the greatest risk of developing CMV infection are:

A) fetuses.
B) immunocompromised individuals.
C) persons older than 40 years.
D) both a and b

Answer 1

both a and b

Question 2

Herpesviruses all share the characteristic of being:

A) rare viruses.
B) associated with bioterrorism agents.
C) cell-associated.
D) only found in the United States.

Answer 2

cell-associated.

Question 3

MATCHING
Match the three types of CMV infection associated with blood transfusion with their appropriate description.

Reinfection

A)CMV strain in the donor's blood that differs from the strain originally infecting the recipient
B)Seronegative recipient is transfused with blood from actively or latently infected donor
C)Seropositive recipient is transfused with blood from CMV antibody-positive or CMV antibody-negative donor

Answer 3

CMV strain in the donor's blood that differs from the strain originally infecting the recipient

Question 4

Cytomegalovirus (CMV)is related to:

A) Epstein-Barr virus (EBV).
B) herpes simplex 1.
C) herpes simplex 2.
D) all of the above.

Question 5

Patients with the highest risk of mortality from CMV are:

A) fetuses.
B) immunocompromised individuals.
C) allograft transplant,seronegative patients who receive tissue from a seropositive donor.
D) all of the above.

Question 6

CMV infection in normal adults and children is:

A) associated with CMV hepatitis as well.
B) asymptomatic in most patients.
C) occasionally a self-limited,mononucleosis-like syndrome.
D) all of the above.

Question 7

Match the infections with the appropriate immunoglobulin response.

Primary infection

A)IgG,but IgM response unknown
B)Specific IgM antibody response
C)IgG (no detectable IgM)

Question 8

A fourfold rise in IgG antibody titer suggests but does not prove __________ CMV infection.

A) recent
B) latent
C) reactivated
D) chronic

Question 9

The great majority of infections in allograft recipients:

A) are transmitted by a donated organ.
B) arise from the reactivation of the recipient's latent virus.
C) are transmitted through transfusion of packed red blood cells.
D) both a and b

Question 10

The most common virus transmitted to the fetus is:

A) malaria.
B) rubella.
C) hepatitis.
D) cytomegalovirus.

Question 11

Cells of tissues that can harbor CMV include:

A) peripheral neutrophilic blood leukocytes.
B) lymphocytes in the circulation..
C) prostate tissue.
D) all of the above.

Question 12

Cytomegalovirus (CMV)is ____________ worldwide.

A) epidemic
B) endemic
C) infrequently seen
D) rarely seen

Question 13

The preferred method for diagnosis of CMV infection is:

A) culture of virus.
B) polymerase chain reaction (PCR).
C) latex agglutination.
D) either a or b

Question 14

Forms of transfusion-acquired cytomegalovirus (CMV)infection include all the following except:

A) primary infection.
B) reactivated infection.
C) reinfection with a different strain.
D) latent infection.

Question 15

The blood product that can transmit cytomegalovirus (CMV)is:

A) platelet concentration.
B) washed red blood cells (RBCs).
C) leukocyte (WBC)concentrates.
D) plasma.

Question 16

All the herpesviruses are relatively large,enveloped ________ viruses.

A) DNA
B) RNA
C) retro
D) both b and c

Question 17

MATCHING
Match the three types of CMV infection associated with blood transfusion with their appropriate description.

Reactivated infection

A)CMV strain in the donor's blood that differs from the strain originally infecting the recipient
B)Seronegative recipient is transfused with blood from actively or latently infected donor
C)Seropositive recipient is transfused with blood from CMV antibody-positive or CMV antibody-negative donor

Question 18

A latent CMV infection is defined as:

A) persistent infections characterized by periods of reactivation.
B) the presence of genetic information in an unexpressed state in the host cell.
C) a condition of a dynamic relationship between the virus and host.
D) all of the above.

Question 19

MATCHING
Match the three types of CMV infection associated with blood transfusion with their appropriate description.

Primary infection

A)CMV strain in the donor's blood that differs from the strain originally infecting the recipient
B)Seronegative recipient is transfused with blood from actively or latently infected donor
C)Seropositive recipient is transfused with blood from CMV antibody-positive or CMV antibody-negative donor

Question 20

Antibodies to early antigens can be associated with:

A) primary infection.
B) reactivated infection.
C) latent infection.
D) either a or b

Question 21

Congenital CMV infection is the most common intrauterine infection.

Question 22

The patient infected with cytomegalovirus has mononucleosis-like symptoms but exhibits a negative Epstein-Barr virus (EBV)test result.

Question 23

Acquired CMV infection is usually asymptomatic and can persist in the host as a chronic or latent infection.

Question 24

Fill in the blanks for the test methods in the table below.Use an answer only once.
Laboratory Diagnosis of Cytomegalovirus (CMV)Infection*

A) Solid-phase agglutination
B) Latex agglutination
C) PCR
D) Chemiluminescent immunoassay

Question 25

Match the infections with the appropriate immunoglobulin response.

Reinfection with strain of CMV different from original strain

A)IgG,but IgM response unknown
B)Specific IgM antibody response
C)IgG (no detectable IgM)

Question 26

Match the infections with the appropriate immunoglobulin response.

Reactivation of latent infection in seropositive IgG patient

A)IgG,but IgM response unknown
B)Specific IgM antibody response
C)IgG (no detectable IgM)

Question 27

CMV serology is recommended for immunocompromised patients.

Question 28

Primary and recurrent maternal CMV infections cannot be transmitted in utero.