Question 1

Match the infections with the appropriate immunoglobulin response.

-Reinfection with strain of CMV different from original strain

Accepted Answer

A) IgG,but IgM response unknown 
B) Specific IgM antibody response 
C) IgG (no detectable IgM) 
A) IgG,but IgM response unknown 
B) Specific IgM antibody response 
C) IgG (no detectable IgM) A

Question 2

Acquired CMV infection is usually asymptomatic and can persist in the host as a chronic or latent infection.

Accepted Answer

A) True 
 B)False  True

Question 3

The great majority of infections in allograft recipients:

Accepted Answer

A)  are transmitted by a donated organ. 
B)  arise from the reactivation of the recipient's latent virus. 
C)  are transmitted through transfusion of packed red blood cells. 
D)  both a and b 
A)  are transmitted by a donated organ. 
B)  arise from the reactivation of the recipient's latent virus. 
C)  are transmitted through transfusion of packed red blood cells. 
D)  both a and b D

Question 4

MATCHING
Match the three types of CMV infection associated with blood transfusion with their appropriate description.

-Primary infection

Accepted Answer

A) CMV strain in the donor's blood that differs from the strain originally infecting the recipient 
B) Seronegative recipient is transfused with blood from actively or latently infected donor 
C) Seropositive recipient is transfused with blood from CMV antibody-positive or CMV antibody-negative donor 
A) CMV strain in the donor's blood that differs from the strain originally infecting the recipient 
B) Seronegative recipient is transfused with blood from actively or latently infected donor 
C) Seropositive recipient is transfused with blood from CMV antibody-positive or CMV antibody-negative donor

Question 5

Match the infections with the appropriate immunoglobulin response.

-Primary infection

Accepted Answer

A) IgG,but IgM response unknown 
B) Specific IgM antibody response 
C) IgG (no detectable IgM) 
A) IgG,but IgM response unknown 
B) Specific IgM antibody response 
C) IgG (no detectable IgM)

Question 6

The preferred method for diagnosis of CMV infection is:

Accepted Answer

A)  culture of virus. 
B)  polymerase chain reaction (PCR). 
C)  latex agglutination. 
D)  either a or b 
A)  culture of virus. 
B)  polymerase chain reaction (PCR). 
C)  latex agglutination. 
D)  either a or b

Question 7

The patient infected with cytomegalovirus has mononucleosis-like symptoms but exhibits a negative Epstein-Barr virus (EBV)test result.

Accepted Answer

A) True 
 B)False

Question 8

A latent CMV infection is defined as:

Accepted Answer

A)  persistent infections characterized by periods of reactivation. 
B)  the presence of genetic information in an unexpressed state in the host cell. 
C)  a condition of a dynamic relationship between the virus and host. 
D)  all of the above. 
A)  persistent infections characterized by periods of reactivation. 
B)  the presence of genetic information in an unexpressed state in the host cell. 
C)  a condition of a dynamic relationship between the virus and host. 
D)  all of the above.

Question 9

MATCHING
Match the three types of CMV infection associated with blood transfusion with their appropriate description.

-Reactivated infection

Accepted Answer

A) CMV strain in the donor's blood that differs from the strain originally infecting the recipient 
B) Seronegative recipient is transfused with blood from actively or latently infected donor 
C) Seropositive recipient is transfused with blood from CMV antibody-positive or CMV antibody-negative donor 
A) CMV strain in the donor's blood that differs from the strain originally infecting the recipient 
B) Seronegative recipient is transfused with blood from actively or latently infected donor 
C) Seropositive recipient is transfused with blood from CMV antibody-positive or CMV antibody-negative donor

Question 10

Cytomegalovirus (CMV)is ____________ worldwide.

Accepted Answer

A)  epidemic 
B)  endemic 
C)  infrequently seen 
D)  rarely seen 
A)  epidemic 
B)  endemic 
C)  infrequently seen 
D)  rarely seen

Question 11

CMV serology is recommended for immunocompromised patients.

Accepted Answer

A) True 
 B)False

Question 12

MATCHING
Match the three types of CMV infection associated with blood transfusion with their appropriate description.

-Reinfection

Accepted Answer

A) CMV strain in the donor's blood that differs from the strain originally infecting the recipient 
B) Seronegative recipient is transfused with blood from actively or latently infected donor 
C) Seropositive recipient is transfused with blood from CMV antibody-positive or CMV antibody-negative donor 
A) CMV strain in the donor's blood that differs from the strain originally infecting the recipient 
B) Seronegative recipient is transfused with blood from actively or latently infected donor 
C) Seropositive recipient is transfused with blood from CMV antibody-positive or CMV antibody-negative donor

Question 13

Cytomegalovirus (CMV)is related to:

Accepted Answer

A)  Epstein-Barr virus (EBV). 
B)  herpes simplex 1. 
C)  herpes simplex 2. 
D)  all of the above. 
A)  Epstein-Barr virus (EBV). 
B)  herpes simplex 1. 
C)  herpes simplex 2. 
D)  all of the above.

Question 14

A fourfold rise in IgG antibody titer suggests but does not prove __________ CMV infection.

Accepted Answer

A)  recent 
B)  latent 
C)  reactivated 
D)  chronic 
A)  recent 
B)  latent 
C)  reactivated 
D)  chronic

Question 15

All the herpesviruses are relatively large,enveloped ________ viruses.

Accepted Answer

A)  DNA 
B)  RNA 
C)  retro 
D)  both b and c 
A)  DNA 
B)  RNA 
C)  retro 
D)  both b and c

Question 16

Antibodies to early antigens can be associated with:

Accepted Answer

A)  primary infection. 
B)  reactivated infection. 
C)  latent infection. 
D)  either a or b 
A)  primary infection. 
B)  reactivated infection. 
C)  latent infection. 
D)  either a or b

Question 17

Primary and recurrent maternal CMV infections cannot be transmitted in utero.

Accepted Answer

A) True 
 B)False

Question 18

Congenital CMV infection is the most common intrauterine infection.

Accepted Answer

A) True 
 B)False

Question 19

Patients with the highest risk of mortality from CMV are:

Accepted Answer

A)  fetuses. 
B)  immunocompromised individuals. 
C)  allograft transplant,seronegative patients who receive tissue from a seropositive donor. 
D)  all of the above. 
A)  fetuses. 
B)  immunocompromised individuals. 
C)  allograft transplant,seronegative patients who receive tissue from a seropositive donor. 
D)  all of the above.

Question 20

Individuals with the greatest risk of developing CMV infection are:

Accepted Answer

A)  fetuses. 
B)  immunocompromised individuals. 
C)  persons older than 40 years. 
D)  both a and b 
A)  fetuses. 
B)  immunocompromised individuals. 
C)  persons older than 40 years. 
D)  both a and b

Exam 21: Cytomegalovirus

Match the infections with the appropriate immunoglobulin response. -Reinfection with strain of CMV different from original strain

Acquired CMV infection is usually asymptomatic and can persist in the host as a chronic or latent infection.

The great majority of infections in allograft recipients:

MATCHING Match the three types of CMV infection associated with blood transfusion with their appropriate description. -Primary infection

Match the infections with the appropriate immunoglobulin response. -Primary infection

The preferred method for diagnosis of CMV infection is:

The patient infected with cytomegalovirus has mononucleosis-like symptoms but exhibits a negative Epstein-Barr virus (EBV)test result.

A latent CMV infection is defined as:

MATCHING Match the three types of CMV infection associated with blood transfusion with their appropriate description. -Reactivated infection

Cytomegalovirus (CMV)is ____________ worldwide.

CMV serology is recommended for immunocompromised patients.

MATCHING Match the three types of CMV infection associated with blood transfusion with their appropriate description. -Reinfection

Cytomegalovirus (CMV)is related to:

A fourfold rise in IgG antibody titer suggests but does not prove __________ CMV infection.

All the herpesviruses are relatively large,enveloped ________ viruses.

Antibodies to early antigens can be associated with:

Primary and recurrent maternal CMV infections cannot be transmitted in utero.

Congenital CMV infection is the most common intrauterine infection.

Patients with the highest risk of mortality from CMV are:

Individuals with the greatest risk of developing CMV infection are:

An Overview of Immunology

Antigens and Antibodies

Cells and Cellular Activities of the Immune System: Granulocytes and Mononuclear Cells

Cells and Cellular Activities of the Immune System: Lymphocytes and Plasma Cells

Soluble Mediators of the Immune System

Safety in the Immunology-Serology Laboratory

Quality Assurance and Quality Control

Basic Serologic Laboratory Techniques

Point-Of-Care Testing

Agglutination Methods

Electrophoresis Techniques

Labeling Techniques in Immunoassay

Automated Procedures

Molecular Techniques

The Immune Response in Infectious Diseases

A Primer on Vaccines

Streptococcal Infections

Syphilis

Vector-Borne Diseases

Toxoplasmosis

Infectious Mononucleosis

Viral Hepatitis

Rubella and Rubeola Infections

Acquired Immunodeficiency Syndrome

Hypersensitivity Reactions

Immunoproliferative Disorders

Autoimmune Disorders

Systemic Lupus Erythematosus

Rheumatoid Arthritis

Solid Organ Transplantation

Bone Marrow Transplantation

Tumor Immunology

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