Deck 30: Alterations of Leukocyte and Lymphoid Function

Question 1

Which description is consistent with chronic myelogenous leukemia (CML)?

A)Defects exist in the ras oncogene, TP53 tumor-suppressor gene, and INK4A, the gene encoding a cell-cycle regulatory protein.
B)Leukocytosis and a predominance of blast cells characterize the bone marrow and peripheral blood. As the immature blasts increase, they replace normal myelocytic cells, megakaryocytes, and erythrocytes.
C)B cells fail to mature into plasma cells that synthesize immunoglobulins.
D)The translocation of genetic material from genes 9 and 22 creates an abnormal, fused protein identified as BCR-ABL1.

Answer 1

The translocation of genetic material from genes 9 and 22 creates an abnormal, fused protein identified as BCR-ABL1.

Question 2

A student is learning about the functions of leukocytes. What statements about these cells are correct? (Select all that apply.)

A)Eosinophilia can result from parasitic infections.
B)Basophilia can be seen in hypersensitivity reactions.
C)Monocytosis is usually seen in acute infections.
D)Lymphocytosis occurs rapidly in bacterial infections.
E)Granulocytopenia can be a life-threatening condition.

Answer 2

Eosinophilia can result from parasitic infections.
Basophilia can be seen in hypersensitivity reactions.
Granulocytopenia can be a life-threatening condition.

Question 3

A patient has been diagnosed with acute lymphocytic leukemia (ALL) and asks the healthcare professional to describe it. What description by the professional is most accurate?

A)ALL is a progressive neoplasm defined by the presence of greater than 30% lymphoblasts in the bone marrow or blood.
B)In ALL, immature blasts cells replace normal myelocytic cells, megakaryocytes, and erythrocytes.
C)B cells fail to mature into plasma cells that synthesize immunoglobulins.
D)The translocation of genetic material from genes 9 and 22 create an abnormal, fused gene identified as BCR-ABL.

Answer 3

ALL is a progressive neoplasm defined by the presence of greater than 30% lymphoblasts in the bone marrow or blood.

Question 4

A student studying microbiology learns which facts about the Epstein-Barr virus (EBV)? (Select all that apply.)

A)Causative organism for infectious mononucleosis
B)Rare mutation may be seen in Burkitt Lymphoma.
C)Implicated in some nasopharyngeal cancers
D)Is only seen along with rare non-Hodgkin lymphomas
E)Immunodeficiency can lead to EBV-positive neoplasms.

Question 5

In infectious mononucleosis (IM), what does the Monospot test detect?

A)Immunoglobulin E (IgE)
B)Immunoglobulin M (IgM)
C)Immunoglobulin G (IgG)
D)Immunoglobulin A (IgA)

Question 6

The two major forms of leukemia, acute and chronic, are classified by which criteria? (Select all that apply.)

A)Predominant cell type
B)Rate of progression
C)Age of individual when cells differentiation occurs
D)Stage of cell development when malignancy first occurs
E)Serum level of leukocytes

Question 7

A person has lab drawn and the white blood cell count is much higher than normal. The healthcare professional understands which facts about this finding? (Select all that apply.)

A)The person has leukocytosis.
B)The person has leukopenia.
C)The person may have an infection.
D)The person may have a myeloproliferative disorder.
E)The person needs a bone marrow biopsy.

Question 8

Reed-Sternberg (RS) cells represent malignant transformation and proliferation of which of these?

A)Interleukin (IL)-1, IL-2, IL-5, and IL-6
B)Tumor necrosis factor-beta
C)B cells
D)T cells

Question 9

Which classic clinical manifestations are symptoms of infectious mononucleosis (IM)? (Select all that apply.)

A)Lymph node enlargement
B)Hepatitis
C)Pharyngitis
D)Edema in the area of the eyes
E)Fever

Question 10

A patient is admitted to the hospital with multiple myeloma (MM). Which diagnostic test should the healthcare professional assess as the priority?

A)Serum potassium level
B)Serum calcium level
C)Bone scan or limb x-rays
D)Bone marrow biopsy

Question 11

Which virus is associated with Burkitt lymphoma in African children?

A)Cytomegalovirus
B)Adenovirus
C)Human papillomavirus
D)Epstein-Barr virus

Question 12

The student studying pathophysiology learns which facts about leukemias? (Select all that apply.)

A)A single progenitor cell undergoes a malignant change.
B)Leukemia is a result of uncontrolled cellular proliferation.
C)Bone marrow becomes overcrowded.
D)Leukocytes are under produced.
E)Hematopoietic cell production is decreased.

Question 13

A patient has splenomegaly on physical examination. What does the healthcare professional understand about this condition? (Select all that apply.)

A)It may be normal so nothing further needs to be done
B)The patient may have an acute infection.
C)Splenomegaly can lead to hepatic failure.
D)Tumors or cysts can cause splenomegaly.
E)Some infiltrative processes can cause it.

Question 14

Early detection of acute leukemia would include which symptoms? (Select all that apply.)

A)Dizziness
B)Paresthesia
C)Anorexia
D)Bruising
E)Bone pain

Question 15

What are the clinical manifestations of advanced non-African Burkitt lymphoma? (Select all that apply.)

A)Abdominal swelling
B)Night sweats
C)Fever
D)Weight gain
E)Dementia

Question 16

A person comes to the healthcare clinic and reports night sweats and fever. The healthcare professional obtains a chest x-ray which shows a mediastinal mass. What other assessment or diagnostic test does the professional provide as a priority?

A)Listen to heart sounds.
B)Assess the patient's skin.
C)Arrange for familial DNA testing.
D)Test blood for anemia.

Question 17

A hospitalized patient's lab work is as follows: WBC 2000, bands 14.8%, and segmented neutrophils 5. The healthcare professional calculates the patient's absolute neutrophil count (ANC). What action does the professional take next?

A)Implements protocols to prevent life-threatening infections
B)Encourages the patient to limit any visitors for the present time
C)Does nothing; this is a normal ANC for the white cell count
D)Holds the patient's medications until the ANC returns to normal

Question 18

Local signs and symptoms of Hodgkin disease-related lymphadenopathy are a result of what?

A)Pressure and ischemia
B)Pressure and obstruction
C)Inflammation and ischemia
D)Inflammation and pressure

Question 19

A person has been diagnosed with acute lymphocytic leukemia (ALL) that is positive for the Philadelphia chromosome. What statement by the healthcare professional is most appropriate?

A)"This is good news and means the ALL is not very aggressive."
B)"This is a very rare finding in adults who have ALL."
C)"We are planning to get your disease in remission, but it will be hard."
D)"You will need colony-stimulating support during your treatment."