Question 1

Reed-Sternberg (RS) cells represent malignant transformation and proliferation of which of these?

Accepted Answer

A) Interleukin (IL)-1, IL-2, IL-5, and IL-6 
B) Tumor necrosis factor-beta 
C) B cells 
D) T cells 
A) Interleukin (IL)-1, IL-2, IL-5, and IL-6 
B) Tumor necrosis factor-beta 
C) B cells 
D) T cells C

Question 2

A student studying microbiology learns which facts about the Epstein-Barr virus (EBV)? (Select all that apply.)

Accepted Answer

A) Causative organism for infectious mononucleosis 
B) Rare mutation may be seen in Burkitt Lymphoma. 
C) Implicated in some nasopharyngeal cancers 
D) Is only seen along with rare non-Hodgkin lymphomas 
E) Immunodeficiency can lead to EBV-positive neoplasms. 
A) Causative organism for infectious mononucleosis 
B) Rare mutation may be seen in Burkitt Lymphoma. 
C) Implicated in some nasopharyngeal cancers 
D) Is only seen along with rare non-Hodgkin lymphomas 
E) Immunodeficiency can lead to EBV-positive neoplasms. A, C, E

Question 3

The student studying pathophysiology learns which facts about leukemias? (Select all that apply.)

Accepted Answer

A) A single progenitor cell undergoes a malignant change. 
B) Leukemia is a result of uncontrolled cellular proliferation. 
C) Bone marrow becomes overcrowded. 
D) Leukocytes are under produced. 
E) Hematopoietic cell production is decreased. 
A) A single progenitor cell undergoes a malignant change. 
B) Leukemia is a result of uncontrolled cellular proliferation. 
C) Bone marrow becomes overcrowded. 
D) Leukocytes are under produced. 
E) Hematopoietic cell production is decreased. A, B, C, E

Question 4

The two major forms of leukemia, acute and chronic, are classified by which criteria? (Select all that apply.)

Accepted Answer

A) Predominant cell type 
B) Rate of progression 
C) Age of individual when cells differentiation occurs 
D) Stage of cell development when malignancy first occurs 
E) Serum level of leukocytes 
A) Predominant cell type 
B) Rate of progression 
C) Age of individual when cells differentiation occurs 
D) Stage of cell development when malignancy first occurs 
E) Serum level of leukocytes

Question 5

Which virus is associated with Burkitt lymphoma in African children?

Accepted Answer

A) Cytomegalovirus 
B) Adenovirus 
C) Human papillomavirus 
D) Epstein-Barr virus 
A) Cytomegalovirus 
B) Adenovirus 
C) Human papillomavirus 
D) Epstein-Barr virus

Question 6

Early detection of acute leukemia would include which symptoms? (Select all that apply.)

Accepted Answer

A) Dizziness 
B) Paresthesia 
C) Anorexia 
D) Bruising 
E) Bone pain 
A) Dizziness 
B) Paresthesia 
C) Anorexia 
D) Bruising 
E) Bone pain

Question 7

A patient is admitted to the hospital with multiple myeloma (MM). Which diagnostic test should the healthcare professional assess as the priority?

Accepted Answer

A) Serum potassium level 
B) Serum calcium level 
C) Bone scan or limb x-rays 
D) Bone marrow biopsy 
A) Serum potassium level 
B) Serum calcium level 
C) Bone scan or limb x-rays 
D) Bone marrow biopsy

Question 8

Which description is consistent with chronic myelogenous leukemia (CML)?

Accepted Answer

A) Defects exist in the ras oncogene, TP53 tumor-suppressor gene, and INK4A, the gene encoding a cell-cycle regulatory protein. 
B) Leukocytosis and a predominance of blast cells characterize the bone marrow and peripheral blood. As the immature blasts increase, they replace normal myelocytic cells, megakaryocytes, and erythrocytes. 
C) B cells fail to mature into plasma cells that synthesize immunoglobulins. 
D) The translocation of genetic material from genes 9 and 22 creates an abnormal, fused protein identified as BCR-ABL1. 
A) Defects exist in the ras oncogene, TP53 tumor-suppressor gene, and INK4A, the gene encoding a cell-cycle regulatory protein. 
B) Leukocytosis and a predominance of blast cells characterize the bone marrow and peripheral blood. As the immature blasts increase, they replace normal myelocytic cells, megakaryocytes, and erythrocytes. 
C) B cells fail to mature into plasma cells that synthesize immunoglobulins. 
D) The translocation of genetic material from genes 9 and 22 creates an abnormal, fused protein identified as BCR-ABL1.

Question 9

A person has been diagnosed with acute lymphocytic leukemia (ALL) that is positive for the Philadelphia chromosome. What statement by the healthcare professional is most appropriate?

Accepted Answer

A) "This is good news and means the ALL is not very aggressive." 
B) "This is a very rare finding in adults who have ALL." 
C) "We are planning to get your disease in remission, but it will be hard." 
D) "You will need colony-stimulating support during your treatment." 
A) "This is good news and means the ALL is not very aggressive." 
B) "This is a very rare finding in adults who have ALL." 
C) "We are planning to get your disease in remission, but it will be hard." 
D) "You will need colony-stimulating support during your treatment."

Question 10

A patient has been diagnosed with acute lymphocytic leukemia (ALL) and asks the healthcare professional to describe it. What description by the professional is most accurate?

Accepted Answer

A) ALL is a progressive neoplasm defined by the presence of greater than 30% lymphoblasts in the bone marrow or blood. 
B) In ALL, immature blasts cells replace normal myelocytic cells, megakaryocytes, and erythrocytes. 
C) B cells fail to mature into plasma cells that synthesize immunoglobulins. 
D) The translocation of genetic material from genes 9 and 22 create an abnormal, fused gene identified as BCR-ABL. 
A) ALL is a progressive neoplasm defined by the presence of greater than 30% lymphoblasts in the bone marrow or blood. 
B) In ALL, immature blasts cells replace normal myelocytic cells, megakaryocytes, and erythrocytes. 
C) B cells fail to mature into plasma cells that synthesize immunoglobulins. 
D) The translocation of genetic material from genes 9 and 22 create an abnormal, fused gene identified as BCR-ABL.

Question 11

A patient has splenomegaly on physical examination. What does the healthcare professional understand about this condition? (Select all that apply.)

Accepted Answer

A) It may be normal so nothing further needs to be done 
B) The patient may have an acute infection. 
C) Splenomegaly can lead to hepatic failure. 
D) Tumors or cysts can cause splenomegaly. 
E) Some infiltrative processes can cause it. 
A) It may be normal so nothing further needs to be done 
B) The patient may have an acute infection. 
C) Splenomegaly can lead to hepatic failure. 
D) Tumors or cysts can cause splenomegaly. 
E) Some infiltrative processes can cause it.

Question 12

A person has lab drawn and the white blood cell count is much higher than normal. The healthcare professional understands which facts about this finding? (Select all that apply.)

Accepted Answer

A) The person has leukocytosis. 
B) The person has leukopenia. 
C) The person may have an infection. 
D) The person may have a myeloproliferative disorder. 
E) The person needs a bone marrow biopsy. 
A) The person has leukocytosis. 
B) The person has leukopenia. 
C) The person may have an infection. 
D) The person may have a myeloproliferative disorder. 
E) The person needs a bone marrow biopsy.

Question 13

A student is learning about the functions of leukocytes. What statements about these cells are correct? (Select all that apply.)

Accepted Answer

A) Eosinophilia can result from parasitic infections. 
B) Basophilia can be seen in hypersensitivity reactions. 
C) Monocytosis is usually seen in acute infections. 
D) Lymphocytosis occurs rapidly in bacterial infections. 
E) Granulocytopenia can be a life-threatening condition. 
A) Eosinophilia can result from parasitic infections. 
B) Basophilia can be seen in hypersensitivity reactions. 
C) Monocytosis is usually seen in acute infections. 
D) Lymphocytosis occurs rapidly in bacterial infections. 
E) Granulocytopenia can be a life-threatening condition.

Question 14

In infectious mononucleosis (IM), what does the Monospot test detect?

Accepted Answer

A) Immunoglobulin E (Ig
E)  
B) Immunoglobulin M (IgM) 
C) Immunoglobulin G (IgG) 
D) Immunoglobulin A (Ig
A)  
A) Immunoglobulin E (Ig
E)  
B) Immunoglobulin M (IgM) 
C) Immunoglobulin G (IgG) 
D) Immunoglobulin A (Ig
A)

Question 15

What are the clinical manifestations of advanced non-African Burkitt lymphoma? (Select all that apply.)

Accepted Answer

A) Abdominal swelling 
B) Night sweats 
C) Fever 
D) Weight gain 
E) Dementia 
A) Abdominal swelling 
B) Night sweats 
C) Fever 
D) Weight gain 
E) Dementia

Question 16

A person comes to the healthcare clinic and reports night sweats and fever. The healthcare professional obtains a chest x-ray which shows a mediastinal mass. What other assessment or diagnostic test does the professional provide as a priority?

Accepted Answer

A) Listen to heart sounds. 
B) Assess the patient's skin. 
C) Arrange for familial DNA testing. 
D) Test blood for anemia. 
A) Listen to heart sounds. 
B) Assess the patient's skin. 
C) Arrange for familial DNA testing. 
D) Test blood for anemia.

Question 17

Local signs and symptoms of Hodgkin disease-related lymphadenopathy are a result of what?

Accepted Answer

A) Pressure and ischemia 
B) Pressure and obstruction 
C) Inflammation and ischemia 
D) Inflammation and pressure 
A) Pressure and ischemia 
B) Pressure and obstruction 
C) Inflammation and ischemia 
D) Inflammation and pressure

Question 18

A hospitalized patient's lab work is as follows: WBC 2000, bands 14.8%, and segmented neutrophils 5. The healthcare professional calculates the patient's absolute neutrophil count (ANC). What action does the professional take next?

Accepted Answer

A) Implements protocols to prevent life-threatening infections 
B) Encourages the patient to limit any visitors for the present time 
C) Does nothing; this is a normal ANC for the white cell count 
D) Holds the patient's medications until the ANC returns to normal 
A) Implements protocols to prevent life-threatening infections 
B) Encourages the patient to limit any visitors for the present time 
C) Does nothing; this is a normal ANC for the white cell count 
D) Holds the patient's medications until the ANC returns to normal

Question 19

Which classic clinical manifestations are symptoms of infectious mononucleosis (IM)? (Select all that apply.)

Accepted Answer

A) Lymph node enlargement 
B) Hepatitis 
C) Pharyngitis 
D) Edema in the area of the eyes 
E) Fever 
A) Lymph node enlargement 
B) Hepatitis 
C) Pharyngitis 
D) Edema in the area of the eyes 
E) Fever

Exam 30: Alterations of Leukocyte and Lymphoid Function

Reed-Sternberg (RS) cells represent malignant transformation and proliferation of which of these?

A student studying microbiology learns which facts about the Epstein-Barr virus (EBV)? (Select all that apply.)

The student studying pathophysiology learns which facts about leukemias? (Select all that apply.)

The two major forms of leukemia, acute and chronic, are classified by which criteria? (Select all that apply.)

Which virus is associated with Burkitt lymphoma in African children?

Early detection of acute leukemia would include which symptoms? (Select all that apply.)

A patient is admitted to the hospital with multiple myeloma (MM). Which diagnostic test should the healthcare professional assess as the priority?

Which description is consistent with chronic myelogenous leukemia (CML)?

A person has been diagnosed with acute lymphocytic leukemia (ALL) that is positive for the Philadelphia chromosome. What statement by the healthcare professional is most appropriate?

A patient has been diagnosed with acute lymphocytic leukemia (ALL) and asks the healthcare professional to describe it. What description by the professional is most accurate?

A patient has splenomegaly on physical examination. What does the healthcare professional understand about this condition? (Select all that apply.)

A person has lab drawn and the white blood cell count is much higher than normal. The healthcare professional understands which facts about this finding? (Select all that apply.)

A student is learning about the functions of leukocytes. What statements about these cells are correct? (Select all that apply.)

In infectious mononucleosis (IM), what does the Monospot test detect?

What are the clinical manifestations of advanced non-African Burkitt lymphoma? (Select all that apply.)

A person comes to the healthcare clinic and reports night sweats and fever. The healthcare professional obtains a chest x-ray which shows a mediastinal mass. What other assessment or diagnostic test does the professional provide as a priority?

Local signs and symptoms of Hodgkin disease-related lymphadenopathy are a result of what?

A hospitalized patient's lab work is as follows: WBC 2000, bands 14.8%, and segmented neutrophils 5. The healthcare professional calculates the patient's absolute neutrophil count (ANC). What action does the professional take next?

Which classic clinical manifestations are symptoms of infectious mononucleosis (IM)? (Select all that apply.)

Cellular Biology

Altered Cellular and Tissue Biology: Environmental Agents

The Cellular Environment: Fluids and Electrolytes, Acids and Bases

Genes and Genetic Diseases

Genes, Environment-Lifestyle, and Common Diseases

Epigenetics and Disease

Innate Immunity: Inflammation and Wound Healing

Adaptive Immunity

Alterations in Immunity and Inflammation

Infection

Stress and Disease

Cancer Biology

Cancer Epidemiology

Cancer in Children

Structure and Function of the Neurologic System

Pain, Temperature Regulation, Sleep, and Sensory Function

Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function

Disorders of the Central and Peripheral Nervous Systems and the Neuromuscular Junction

Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders

Alterations of Neurologic Function in Children

Mechanisms of Hormonal Regulation

Alterations of Hormonal Regulation

Obesity and Disorders of Nutrition

Structure and Function of the Reproductive Systems

Alterations of the Female Reproductive System

Alterations of the Male Reproductive System

Sexually Transmitted Infections

Structure and Function of the Hematologic System

Alterations of Erythrocytes, Platelets, and Hemostatic Function

Alterations of Hematologic Function in Children

Structure and Function of the Cardiovascular and Lymphatic Systems

Alterations of Cardiovascular Function

Alterations of Cardiovascular Function in Children

Structure and Function of the Pulmonary System

Alterations of Pulmonary Function

Alterations of Pulmonary Function in Children

Structure and Function of the Renal and Urologic Systems

Alterations of Renal and Urinary Tract Function

Alterations of Renal and Urinary Tract Function in Children

Structure and Function of the Digestive System

Alterations of Digestive Function

Alterations of Digestive Function in Children

Structure and Function of the Musculoskeletal System

Alterations of Musculoskeletal Function

Alterations of Musculoskeletal Function in Children

Structure, Function, and Disorders of the Integument

Alterations of the Integument in Children

Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults

Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children

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