Exam 11: Hypersensitivity

Experimental autoimmune encephalomyelitis (EAE) is a mouse model of a human organ-specific autoimmune disease mediated by T lymphocytes. In EAE, rodents are immunized with proteins found in the myelin sheath of central nervous system neurons. EAE is a model for which of the following human diseases?

Which of the following is a common cause of hypersensitivity diseases?

An 8-year-old boy from the intermountain region of the United States is brought to the pediatrician with fever, rash, and pain in his knees and ankles. Pericarditis is evident on auscultation, and echocardiography confirms mitral valve regurgitation. Three weeks before this episode, the patient had experienced a sore throat but had not received medical attention. High titers of antistreptococcal antibodies are present in the serum. This child's disease is a result of which one of the following phenomena?

A 26-year-old African-American woman visits her physician because of a prominent rash over her nose and cheeks, which she first noticed following her return from a vacation in Jamaica. She also complains of fever, fatigue, weight loss, and joint pain over the last several months. Serologic tests are conclusive for systemic lupus erythematosus (SLE), an autoimmune disease that can manifest clinically with rashes, arthritis, glomerulonephritis, hemolytic anemia, thrombocytopenia (low platelet count), and central nervous system involvement. The principal diagnostic test result specific for this condition is a high titer of autoantibodies against which of the following?

A 14-year-old boy is brought to the pediatrician's office in mid summer because of an itchy, blistering rash on his calves and forearms. The rash developed 24 hours after he returned from a weekend Boy Scout camping trip. The pediatrician suspects the lesion is caused by poison ivy. If the doctor is correct, which one of the following is NOT a prominent component in the immunologic mechanisms causing the skin lesions?

Which of the following is NOT associated with increased relative risk of developing systemic lupus erythematosus?

In which of the following disorders is the underlying pathogenic mechanism NOT due to antibody-mediated damage to cells or tissues?

Which of the following conditions is NOT associated with immune complex deposition?

All of the following are effector mechanisms of antibody-mediated disease EXCEPT:

Which of the following would NOT be a likely therapy for treating autoimmune diseases?

Individuals with the class I HLA-B27 allele have a 90-fold greater chance of developing which of the following inflammatory diseases, relative to HLA-B27-negative individuals?

Which of the following statements about immune complex-mediated diseases is NOT true?

Which one of the following statements concerning autoimmune disease is true?

Which type of hypersensitivity disease is caused by deposition of antigen-antibody complexes in blood vessel walls?