Question 1

Which of the following antimicrobial agents has a dose-dependent activity on microorganisms?

Accepted Answer

A)  The glycoprotein vancomycin 
B)  The glycoprotein teicoplanin 
C)  The penicillin amoxycillin 
D)  The aminoglycoside gentamicin 
A)  The glycoprotein vancomycin 
B)  The glycoprotein teicoplanin 
C)  The penicillin amoxycillin 
D)  The aminoglycoside gentamicin D

Question 2

The actions of streptomycin and amikacin:

Accepted Answer

A)  are considered first-line agents for tuberculosis. 
B)  are ineffective for the bactericidal phase. 
C)  interfere with protein synthesis. 
D)  are best mediated by the oral route. 
A)  are considered first-line agents for tuberculosis. 
B)  are ineffective for the bactericidal phase. 
C)  interfere with protein synthesis. 
D)  are best mediated by the oral route. C

Question 3

An example of an antibacterial agent that attacks the cell wall is:

Accepted Answer

A)  nitrofurantoin. 
B)  tetracycline. 
C)  neomycin. 
D)  penicillin. 
A)  nitrofurantoin. 
B)  tetracycline. 
C)  neomycin. 
D)  penicillin. D

Question 4

If a microbe has developed resistance to a certain antimicrobial preparation,the prescriber should:

Accepted Answer

A)  increase the frequency of the dose of the antimicrobial. 
B)  increase the dose of the antimicrobial. 
C)  determine which antimicrobial the microbe may be sensitive to. 
D)  prescribe topical preparations only. 
A)  increase the frequency of the dose of the antimicrobial. 
B)  increase the dose of the antimicrobial. 
C)  determine which antimicrobial the microbe may be sensitive to. 
D)  prescribe topical preparations only.

Question 5

An antimicrobial drug mechanism of action generally regarded as bacteriostatic is one that:

Accepted Answer

A)  interferes with metabolic processes. 
B)  inhibits cell wall synthesis. 
C)  promotes protein synthesis. 
D)  disrupts cell membranes. 
A)  interferes with metabolic processes. 
B)  inhibits cell wall synthesis. 
C)  promotes protein synthesis. 
D)  disrupts cell membranes.

Question 6

An antimicrobial agent with a narrow spectrum of activity reflects a drug that has:

Accepted Answer

A)  only a weak antibiotic action. 
B)  effectiveness against a relatively small number of microbes. 
C)  a low potency. 
D)  a narrow margin of safety. 
A)  only a weak antibiotic action. 
B)  effectiveness against a relatively small number of microbes. 
C)  a low potency. 
D)  a narrow margin of safety.

Question 7

Which anti-infective agent would have the highest risk if used in pregnancy?

Accepted Answer

A)  Selected penicillins 
B)  Nystatin 
C)  Amphotericin 
D)  Nitrofurantoin 
A)  Selected penicillins 
B)  Nystatin 
C)  Amphotericin 
D)  Nitrofurantoin

Question 8

Which one of the following statements is relevant regarding antimicrobial drugs that are time-dependent?

Accepted Answer

A)  It is important to measure peak and trough plasma concentrations. 
B)  The plasma drug concentration must be 60% of the maximum effective concentration for it to be effective. 
C)  An increase in dose will result in an increased effect. 
D)  The period above the minimum effective concentration determines the effectiveness of treatment. 
A)  It is important to measure peak and trough plasma concentrations. 
B)  The plasma drug concentration must be 60% of the maximum effective concentration for it to be effective. 
C)  An increase in dose will result in an increased effect. 
D)  The period above the minimum effective concentration determines the effectiveness of treatment.

Question 9

It is recommended that surgical prophylaxis with antibiotics is not undertaken with a:

Accepted Answer

A)  mastectomy. 
B)  coronary bypass surgery. 
C)  splenectomy. 
D)  large bowel resection. 
A)  mastectomy. 
B)  coronary bypass surgery. 
C)  splenectomy. 
D)  large bowel resection.

Question 10

Which of the following is NOT a likely cause of antimicrobial resistance?

Accepted Answer

A)  Using narrow-spectrum antibiotics instead of broad-spectrum antibiotics 
B)  Excessive use of antibiotics in animals bred for human consumption 
C)  Failure to conform to the dosing regime 
D)  Spraying excess antibiotic in the air after drawing it up for injection 
A)  Using narrow-spectrum antibiotics instead of broad-spectrum antibiotics 
B)  Excessive use of antibiotics in animals bred for human consumption 
C)  Failure to conform to the dosing regime 
D)  Spraying excess antibiotic in the air after drawing it up for injection

Question 11

Which of the following antimicrobial agents inhibits DNA replication?

Accepted Answer

A)  Linezolid 
B)  Mupirocin 
C)  Colistin 
D)  Norfloxacin 
A)  Linezolid 
B)  Mupirocin 
C)  Colistin 
D)  Norfloxacin

Question 12

Individuals with antibiotic-associated colitis should be treated with:

Accepted Answer

A)  codeine. 
B)  cholestyramine. 
C)  loperamide. 
D)  tetracycline. 
A)  codeine. 
B)  cholestyramine. 
C)  loperamide. 
D)  tetracycline.

Exam 67: Introduction to Chemotherapy

Which of the following antimicrobial agents has a dose-dependent activity on microorganisms?

The actions of streptomycin and amikacin:

An example of an antibacterial agent that attacks the cell wall is:

If a microbe has developed resistance to a certain antimicrobial preparation,the prescriber should:

An antimicrobial drug mechanism of action generally regarded as bacteriostatic is one that:

An antimicrobial agent with a narrow spectrum of activity reflects a drug that has:

Which anti-infective agent would have the highest risk if used in pregnancy?

Which one of the following statements is relevant regarding antimicrobial drugs that are time-dependent?

It is recommended that surgical prophylaxis with antibiotics is not undertaken with a:

Which of the following is NOT a likely cause of antimicrobial resistance?

Which of the following antimicrobial agents inhibits DNA replication?

Individuals with antibiotic-associated colitis should be treated with:

Sociocultural Aspects

Health Professionals and the Law

Ethical Issues

the Roles and Responsibilities of Health Professionals in Medicine Adherence, Education and Advocacy

the Roles and Responsibilities of Health Professionals in Medicine Management

Medicine Formulations, Storage and Routes of Administration

the Clinical Decision-making Process

Medicine Administration Strategies and Documentation

Medication Errors

Management of Common Adverse Drug Reactions

Risk Communication: Balancing the Benefits and Risks of Drug Treatment

Drug Nomenclature

Pharmacokinetics: Absorption and Distribution

Pharmacokinetics Metabolism and Excretion

Drug Interactions

Pharmacodynamics

Drug Development, Evaluation and Safety

Genetic Considerations in Pharmacology

Pharmacokinetic Factors That Modify Drug Action

Paediatric and Geriatric Pharmacology

Poisoning and Envenomation

the Management of Acute Clinical Overdose

Contemporary Drugs of Abuse

Drug Abuse in Sport

General Aspects of Neuropharmacology

Adrenergic Pharmacology

Cholinergic Pharmacology

An Introduction to Chemical Mediators

Histamine and Antihistamines

Prostaglandins and Serotonin

Nitric Oxide and the Endothelins

General concepts of Psychopharmacology

Antipsychotics

Anxiolytics and Hypnotics

Antidepressants and Mood Stabilisers

Medicines Used in Neurodegenerative Disorders

Antiseizure Agents and Muscle Relaxants

Central Nervous System Stimulants

Opioid Analgesics

Anti-inflammatory, Antipyretic and Non-opioid Analgesic Agents

Medicines Used to Treat Migraine

General Anaesthesia

Local Anesthesia

Medicines Used to Lower Blood Lipids

Antihypertensive Agents

Medicines Used to Promote Tissue Perfusion

Antithrombotic, Fibrinolytic and Haemostatic Agents

Diuretics and Other Renal Medicines

Topic: Medicines Used to Treat Heart Failure

Medicines Used to Treat Cardiac Dysrhythmia

Fluid and Potassium Imbalances

Antianaemic Agents

Medicines Used to Maintain Gas Exchange

Medicines for Upper Respiratory Tract Conditions

Upper Gastrointestinal Tract Medicines

Lower Castrointestinal Tract Medicines

Antiemetic Agents

Enteral and Parenteral Nutrition

Medicines and the Pituitary Gland

Medicines and the Thyroid

Medicines and the Pancreas

Medicines Affecting the Adrenal Cortex

Medicines and the Gonads

Medicines and Bone Metabolism

Hyperuricaemia and Gout

Obesity and Its Treatment

Sulfonamides and Trimethoprim