To Mount the Most Effective Antibody Response That Results in the Synthesis

Multiple Choice

To mount the most effective antibody response that results in the synthesis of high-affinity antibodies,which of the following must occur? (Select all that apply.)

A) recognition of thymus-independent (TI) antigens
B) isotype switching
C) increased expression of TLR9 by B cells
D) affinity maturation
E) decreased expression of CD40 by B cells.