In T Cells,allelic Exclusion of the α-Chain Locus Is Relatively

Essay

In T cells,allelic exclusion of the α-chain locus is relatively ineffective,resulting in the production of some T cells with two T-cell receptors of differing antigen specificity on their cell surface.
A.Will both these receptors have to pass positive selection for the cell to survive? Explain your answer.
B.Will both receptors have to pass negative selection for the cell to survive? Explain your answer.
C.Is there a potential problem in having T cells with dual specificity surviving these selection processes and being exported to the periphery?