Essay
A.What are the two main checkpoints of B-cell development in the bone marrow?
B.What is the fate of developing B cells that produce (i)functional or (ii)nonfunctional heavy and light chains?
C.Explain how these two checkpoints correlate with the process of allelic exclusion that ensures that only one heavy-chain locus and one light-chain locus produce functional gene products.
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A.Checkpoint 1 is marked by the formatio...View Answer
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