What Experiment Led to the Identification of the DSCR Down

Multiple Choice

What experiment led to the identification of the DSCR Down Syndrome Critical Region ?

A) an extra DSCR was injected into yeast cells
B) transgenic humans were developed that had a duplicated DSCR
C) a mouse model was developed lacking the DSCR
D) cancer cells were sequenced to identify the VEGF gene
E) a mouse model was developed trisomic for the DSCR