Which of the Following Statements Is TRUE

Multiple Choice

Which of the following statements is TRUE?

A) In general,inversion and translocation heterozygotes are as fertile as organisms whose chromosomes are in the standard arrangement.
B) Inversions and translocations are without evolutionary significance.
C) Translocations may be pericentric or paracentric.
D) Individuals with familial Down syndrome are trisomic and have 47 chromosomes.
E) Familial Down syndrome is caused by a translocation involving chromosome 21.