In Mammals, Pluripotent Cells Occur Naturally in the Early Embryo

Essay

In mammals, pluripotent cells occur naturally in the early embryo but pluripotent cell lines can also be artificially created. The first approach was to make embryonic stem cell lines from cells isolated from early embryos. More recently, pluripotent cell lines have been made by artificially changing the epigenetic settings of differentiated cells. What is involved in the latter case?