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Essay

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While linkage is a ____1_____ phenomenon, association is a _____2_____ property. Linkage is concerned with seeking to identify the map relationship between two or more ___3___, such as disease and marker ___3____, by analysing samples from individuals within ____4____. Association, on the other hand, is a relationship between ____5____and is studied by analysing samples from individuals within ____6____. Linkage works over ____7____ distances whereas, in practice, association works over very ____8_____ distances. If allele A*1 is shown to be positively associated with a complex disease it would be described as a disease ____9____ factor, and if allele A*2 is negatively associated with the disease it would be described as a ____10____ factor