How Does the Cas9 System Target Where It Produces a Double-Strand

Multiple Choice

How does the Cas9 system target where it produces a double-strand break in the DNA?

A) A guide RNA molecule is associated with Cas9 and will direct Cas9 to bind at sequences complementary to the guide RNA.
B) The Cas9 protein contains amino acids that can interact with specific sequences in the DNA, targeting Cas9 to those specific sites.
C) The Cas9 protein binds to a recombinase, allowing it to disable the gene of interest.
D) A guide RNA molecule associated with Cas9 provides the catalytic activity to cleave the DNA where Cas9 binds.