A 56-Year-Old Obese Woman Suffering from Heartburn and Regurgitation of Acid

Multiple Choice

A 56-year-old obese woman suffering from heartburn and regurgitation of acid saliva after large meals is treated with cimetidine. During cimetidine treatment, her serum creatinine concentration increases significantly. The increase in serum creatinine with cimetidine treatment is most likely due to:

A) Being reabsorbed by the nephron in exchange for creatinine
B) Blocking synthesis of creatinine by skeletal muscle
C) Causing acute renal failure
D) Competing with creatinine for renal tubular secretion
E) Inhibiting uptake of creatinine ingested with food