A Middle-Aged Man Is Evaluated for Polydipsia and Polyuria

Multiple Choice

A middle-aged man is evaluated for polydipsia and polyuria. His 24-hour urine volume is 7.0 L with a low osmolality, and is negative for red blood cells, leukocytes, protein, and glucose. His blood pressure and heart rate are both normal. Which of the following is a likely cause of polyuria in this patient?

A) Acute attack of diabetes mellitus without glucosuria
B) Acute renal failure with a severe decrease in glomerular filtration rate (GFR)
C) Cerebrovascular accident damaging the anterior pituitary gland
D) Renal supersensitivity to the effects of antidiuretic hormone (ADH)
E) Suppression of ADH secretion due to polydipsia