Crossing Over Is Often Reduced Around Centromeric Regions of Chromosomes

Multiple Choice

Crossing over is often reduced around centromeric regions of chromosomes. If you were trying to construct a genetic map of two linked marker loci in this region, how would the genetic map correspond to the physical map?

A) The genetic map will underestimate the distance between markers because the low recombination rate will suggest that the markers are very close to one another when they could be physically far apart.
B) The genetic map will underestimate the distance between markers because the markers will segregate independently in meiosis.
C) The genetic map will overestimate the distance between markers because the low recombination rate will make it appear that they are far from one another when they could be physically close to one another.
D) The genetic map will overestimate the distance between markers because rates of crossing over are not the same at all places on all chromosomes.
E) The genetic and physical maps will precisely correspond since recombination rates at the centromere are lower and more predictable.