You Want to Calculate the Frequency of the Allele Causing

Multiple Choice

You want to calculate the frequency of the allele causing sickle cell disease in your patients, and you know the genotypes of every individual. Assuming the population is not in Hardy- Weinberg equilibrium due to population substructure, which method can be used to calculate allele frequency?

A) genotype proportion method
B) binomial expansion
C) chi- square test
D) allele- counting method
E) square root method