In Disseminated Intravascular Coagulation (DIC),what Activates the Coagulation Cascade

Multiple Choice

In disseminated intravascular coagulation (DIC) ,what activates the coagulation cascade?

A) Cytokines, such as platelet-activating factor (PAF) , and tumor necrosis factor- alpha (TNF-α)
B) Thromboxane A, causing platelets to aggregate and consume clotting factors
C) Tissue factor (TF) located in the endothelial layer of blood vessels and subcutaneous tissue
D) Endotoxins from gram-negative and gram-positive bacteria circulating in the bloodstream