The P53 Gene Is an Important Tumor Suppressor Gene in Our

Multiple Choice

The p53 gene is an important tumor suppressor gene in our genome. It codes for a transcription regulatory protein that can assemble into tetramers. A number of mutations in p53 render the protein inactive. These mutant protein molecules form mixed tetramers with wild-type p53 proteins and, in this case, the tetramer is inactive. The mutations can therefore be categorized as …

A) null.
B) gain-of-function.
C) recessive lethal.
D) dominant-negative.
E) suppressor.