Indicate Whether Each of the Following Descriptions Better Applies to Forward

Short Answer

Indicate whether each of the following descriptions better applies to forward (F) or reverse (R) genetics. Your answer would be a four-letter string composed of letters F and R only, e.g. RFFF.
( ) It involves new gene discovery by genetic screens.
( ) It may also be called genome editing.
( ) In this approach, mutations are introduced deterministically in a known gene.
( ) It is involved in creating knockout mice lacking a particular gene.