If Cells That Have Started Mitosis Are Treated with Nocodazole

Multiple Choice

If cells that have started mitosis are treated with nocodazole, a drug that depolymerizes microtubules, what would you expect to happen? Where would you expect Mad2 protein to be localized?

A) The cells would arrest in prometaphase; Mad2 would be localized to the spindle poles.
B) The cells would arrest in telophase; Mad2 would be localized to the spindle poles.
C) The cells would immediately enter anaphase, finish mitosis, and enter G₁; Mad2 would be localized to the spindle poles.
D) The cells would arrest in prometaphase; Mad2 would be localized to almost all kinetochores.
E) The cells would arrest in telophase; Mad2 would be localized to almost all kinetochores.