Question 1

What is the MOST common type of activated B cell? What are three other types and what kind of antigens do they typically recognize?

Accepted Answer

The answer of What is the MOST common type of...

Question 2

Why is it advantageous for most plasma cells to die by apoptosis at the end of an infection?

Accepted Answer

The answer of Why is it advantageous for most plasma...

Question 3

Which of the following statements are TRUE about ?? T cells and B-1 B cells?

Accepted Answer

A) Both can self-renew in the periphery and do not need to be replenished from primary lymphoid tissues. 
B) Both have identical lymphocyte receptors to one another. 
C) Both respond to their antigens via high-affinity receptor responses. 
D) All of the answers are true. 
E) None of the answers are true.

Question 4

Which of the following is considered to be the "master regulator" of terminal plasma cell differentiation?

Accepted Answer

A) Blimp-1 
B) IRF-4 
C) Pax-5 
D) Bcl-6 
E) NF- ? B

Question 5

Which cells that are found within GC light zones are generally NOT found in the GC dark zones?

Accepted Answer

A) Differentiating B cells. 
B) TFH cells. 
C) FDCs. 
D) Naïve IgD+ B cells that are not participating in the response to the antigen. 
E) None of the answers is correct.

Question 6

What is AID, what does it do, and what two B cell processes cannot happen without it?

Accepted Answer

The answer of What is AID, what does it do,...

Question 7

Which of the following does NOT occur shortly following oligomerization of the BCR upon antigen binding?

Accepted Answer

A) Movement of the BCR complex into areas of the membrane called "lipid rafts". 
B) Positioning of Ig. ? and g ? to allow for phosphorylation of their ITAM motifs 
C) Positioning of CD3 to allow for phosphorylation of its ITAM motifs. 
D) Formation of clathrin-coated pits around BCR complex. 
E) All of the answers occur.

Question 8

The follicular mantle zone consists primarily of which of the following?

Accepted Answer

A) Follicular dendritic cells. 
B) Naïve IgD+ B cells that are not participating in the response against the antigen. 
C) TFH cells. 
D) Plasmacytoid dendritic cells. 
E) None of the answers are correct.

Question 9

A knockout of which of the following genes results in the inability to form germinal centers?

Accepted Answer

A) Blimp-1 
B) IRF-4 
C) Pax-5 
D) Bcl-6 
E) NF- ? B

Question 10

Which of the following statements is TRUE about B-1 B cells and MZB cells?

Accepted Answer

A) Both are self-renewing in the periphery, not requiring replacement from bone marrow. 
B) Both can respond to TI antigen. 
C) Both do not undergo SHM. 
D) Both are self-renewing in the periphery, not requiring replacement from bone marrow, and can respond to TI antigen. 
E) None of the answers are true.

Question 11

After encountering antigen, B cells express all of the following EXCEPT

Accepted Answer

A) CCR7. 
B) CCL19. 
C) CXCR5. 
D) EBI2. 
E) All of the options are expressed.

Question 12

AID converts cytosine into which of the following bases?

Accepted Answer

A) Adenine 
B) Thymine 
C) Deoxyuridine 
D) Guanine 
E) None of the answers are correct.

Question 13

Which factors on the surfaces of B cells and T cells, through their interaction, are required to allow germinal center formation to occur?

Accepted Answer

A) CD40 and CD40L. 
B) Fas and FasL. 
C) CD28 and CD80/86. 
D) TCR and MHC class II. 
E) None of the answers are correct.

Question 14

Which of the following is or appears to be controlled by Blimp-1 during plasma cell differentiation?

Accepted Answer

A) Exit from the cell cycle. 
B) Transitioning from membrane-bound to secreted IgM. 
C) Loss of MHC class II from the cell surface. 
D) All of the answers are correct. 
E) None of the answers are correct.

Question 15

Which of the following do you expect would be actively functioning in a B cell that had migrated to a germinal center?

Accepted Answer

A) RAG1 
B) Artemis 
C) AID 
D) Ku70 
E) None of the answers are correct.

Question 16

Which of the following factors is thought to induce expression of Blimp-1?

Accepted Answer

A) IRF-4 
B) Pax-5 
C) Bcl-6 
D) NF- ? B 
E) None of the answers are correct.

Question 17

To which compartment in the body can long-lived plasma cells potentially be retained for the lifetime of the individual?

Accepted Answer

A) Medullary cords of the lymph node. 
B) Germinal center. 
C) Bone marrow. 
D) Red pulp of spleen. 
E) None of the answers are correct.

Question 18

What molecular events occur when a B cell encounters its cognate antigen for the first time? Describe the events occurring both inside and outside the cell membrane.

Accepted Answer

The answer of What molecular events occur when a B...

Question 19

The B-cell coreceptor CD21 associates with which host molecule?

Accepted Answer

A) C3d 
B) CD19 
C) The BCR 
D) Fc receptors 
E) None of the answers are correct.

Question 20

Blimp-1 represses the expression of which of the following transcription factors?

Accepted Answer

A) Blimp-1 
B) IRF-4 
C) Pax-5 
D) Bcl-6 
E) NF- ? B

Exam 11: B-Cell Activation, Differentiation, and Memory

What is the MOST common type of activated B cell? What are three other types and what kind of antigens do they typically recognize?

Why is it advantageous for most plasma cells to die by apoptosis at the end of an infection?

Which of the following statements are TRUE about ?? T cells and B-1 B cells?

Which of the following is considered to be the "master regulator" of terminal plasma cell differentiation?

Which cells that are found within GC light zones are generally NOT found in the GC dark zones?

What is AID, what does it do, and what two B cell processes cannot happen without it?

Which of the following does NOT occur shortly following oligomerization of the BCR upon antigen binding?

The follicular mantle zone consists primarily of which of the following?

A knockout of which of the following genes results in the inability to form germinal centers?

Which of the following statements is TRUE about B-1 B cells and MZB cells?

After encountering antigen, B cells express all of the following EXCEPT

AID converts cytosine into which of the following bases?

Which factors on the surfaces of B cells and T cells, through their interaction, are required to allow germinal center formation to occur?

Which of the following is or appears to be controlled by Blimp-1 during plasma cell differentiation?

Which of the following do you expect would be actively functioning in a B cell that had migrated to a germinal center?

Which of the following factors is thought to induce expression of Blimp-1?

To which compartment in the body can long-lived plasma cells potentially be retained for the lifetime of the individual?

What molecular events occur when a B cell encounters its cognate antigen for the first time? Describe the events occurring both inside and outside the cell membrane.

The B-cell coreceptor CD21 associates with which host molecule?

Blimp-1 represses the expression of which of the following transcription factors?