Multiple Choice
How does allelic exclusion prevent multiple heavy-chain rearrangements from occurring in pre-B cells?
A) RAG1 and RAG2 are downregulated, and TdT activity is lost so that no additional heavy-chain rearrangements may take place.
B) RAG1 is upregulated whereas RAG2 and TdT are downregulated to prevent heavy-chain recombination on the second set of chromosomes.
C) RAG1 and RAG2 induce silencing of the second alleles for VH-DJH rearrangement.
D) TdT initiates light-chain rearrangement.
E) TdT releases a cytokine to trigger apoptosis in the pre-B cell.
Correct Answer:
Verified
Correct Answer:
Verified
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