At Which Point in the Variable Segments Does the RAG1/2

Multiple Choice

At which point in the variable segments does the RAG1/2 complex introduce a single-strand break into the DNA during somatic rearrangement?

A) Between the coding region and the conserved heptamer
B) Between the conserved heptamer and the 12-bp spacer
C) Between the 23-bp spacer and the conserved nonamer
D) Between the nonamer and 12-bp spacer
E) None of the answers are correct.