Short Answer
In the case of Commonwealth v. Gaynor, a jury convicted the defendant of rape and murder of four women over a period of time. Investigators saved human material from the private areas of the women that experts much later tested for DNA markers related to identity. His attack on the DNA evidence consisted of arguing that the company that conducted the tests could not distinguish DNA from separate sources, and he challenged the way the tests were conducted. Additionally, he questioned the company's math and suggested their use of a genetic database as being inadequate. How did the court rule on the various challenges? The DNA case challenges seem to go more to the mechanics of the testing than to questioning the scientific validity of DNA.
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