A 15-Year-Old Girl Develops Malaise, Headache, and Low-Grade Fever, Followed

Multiple Choice

A 15-year-old girl develops malaise, headache, and low-grade fever, followed by pharyngitis and cervical lymph node enlargement as a result of infectious mononucleosis caused by Epstein-Barr virus (EBV) . Her acute symptoms resolve within 2 weeks, and the fatigue improves within 3 months. All of the following are required for CD8⁺ cytotoxic T lymphocyte (CTL) recognition and killing of EBV-infected cells EXCEPT:

A) β₂-Microglobulin
B) HLA-A, -B or -C
C) CD28
D) LFA-1 (leukocyte function-associated antigen-1)
E) TAP (transporter associated with antigen processing)