Question 1

Matching
The tumor necrosis factor (TNF) family of proteins includes several soluble and membrane proteins that share structural homologies.
 All members of this family bind to members of the TNF-receptor family of molecules expressed on cell surfaces.
TNF-R family members are structurally homologous to one another and utilize similar signal transduction pathways.
For each description of a TNF or a TNF-R family member in questions , select the term listed in options A-E that best matches it.
-Expressed on many cells types, its cytoplasmic tail includes a death domain, binds TNF-receptor associated death domain (TRADD), and initiates a pro-apoptotic signaling cascade.

Accepted Answer

A)  TNF-RI
B)  CD40
C)  Fas ligand
D)  RANK
E)  Lymphotoxin A

Question 2

For each of the following descriptions of a chemokine or chemokine receptor, select the chemokine or chemokine receptor (A-G) that most closely matches it.
-Important in dendritic cell and T cell localization in lymph nodes

Accepted Answer

A)  CXCL8 (IL-8) 
B)  CXCL10 (IP-10) 
C)  CCL19 (EL
C)  
D)  CCL11 (Eotaxin) 
E)  CCR5F) CXCR1G) CX3CL1 (Fractalkine)  C

Question 3

For each of the descriptions of a biologic function in questions , select the T cell-derived cytokine (A-E) that matches it.
-Inhibits proliferation and differentiation of T cells and the activation of macrophages

Accepted Answer

A)  Interferon-g
B)  Interleukin (IL) -4
C)  IL-5
D)  Transforming growth factor-b
E)  Lymphotoxin D

Question 4

Matching
The tumor necrosis factor (TNF) family of proteins includes several soluble and membrane proteins that share structural homologies.
 All members of this family bind to members of the TNF-receptor family of molecules expressed on cell surfaces.
TNF-R family members are structurally homologous to one another and utilize similar signal transduction pathways.
For each description of a TNF or a TNF-R family member in questions , select the term listed in options A-E that best matches it.
-Produced by T cells and binds to the same receptors as does TNF-a produced by macrophages

Accepted Answer

A)  TNF-RI
B)  CD40
C)  Fas ligand
D)  RANK
E)  Lymphotoxin

Question 5

For each of the following descriptions of a chemokine or chemokine receptor, select the chemokine or chemokine receptor (A-G) that most closely matches it.
-Mediates neutrophil recruitment into tissues

Accepted Answer

A)  CXCL8 (IL-8) 
B)  CXCL10 (IP-10) 
C)  CCL19 (EL
C)  
D)  CCL11 (Eotaxin) 
E)  CCR5F) CXCR1G) CX3CL1 (Fractalkine)

Question 6

For each of the descriptions of a biologic function in questions , select the T cell-derived cytokine (A-E) that matches it.
-Induces B cell isotype switching to IgE production

Accepted Answer

A)  Interferon-g
B)  Interleukin (IL) -4
C)  IL-5
D)  Transforming growth factor-b
E)  Lymphotoxin

Question 7

Matching
The tumor necrosis factor (TNF) family of proteins includes several soluble and membrane proteins that share structural homologies.
 All members of this family bind to members of the TNF-receptor family of molecules expressed on cell surfaces.
TNF-R family members are structurally homologous to one another and utilize similar signal transduction pathways.
For each description of a TNF or a TNF-R family member in questions , select the term listed in options A-E that best matches it.
-Expressed on macrophages and B lymphocytes, this receptor plays an important role in the helper T cell-mediated effector functions.

Accepted Answer

A)  TNF-RI
B)  CD40
C)  Fas ligand
D)  RANK
E)  Lymphotoxin

Question 8

Matching
The tumor necrosis factor (TNF) family of proteins includes several soluble and membrane proteins that share structural homologies.
 All members of this family bind to members of the TNF-receptor family of molecules expressed on cell surfaces.
TNF-R family members are structurally homologous to one another and utilize similar signal transduction pathways.
For each description of a TNF or a TNF-R family member in questions , select the term listed in options A-E that best matches it.
-Expressed on osteoclasts, this receptor is important in remodeling bone.

Accepted Answer

A)  TNF-RI
B)  CD40
C)  Fas ligand
D)  RANK
E)  Lymphotoxin

Question 9

For each of the following descriptions of a chemokine or chemokine receptor, select the chemokine or chemokine receptor (A-G) that most closely matches it.
-Important mediator of inflammatory component of immediate hypersensitivity reactions

Accepted Answer

A)  CXCL8 (IL-8) 
B)  CXCL10 (IP-10) 
C)  CCL19 (EL
C)  
D)  CCL11 (Eotaxin) 
E)  CCR5F) CXCR1G) CX3CL1 (Fractalkine)

Question 10

For each of the descriptions of a biologic function in questions , select the T cell-derived cytokine (A-E) that matches it.
-Stimulates growth and activation of eosinophils

Accepted Answer

A)  Interferon-g
B)  Interleukin (IL) -4
C)  IL-5
D)  Transforming growth factor-b
E)  Lymphotoxin

Question 11

For each of the following descriptions of a chemokine or chemokine receptor, select the chemokine or chemokine receptor (A-G) that most closely matches it.
-Binds to interleukin-8

Accepted Answer

A)  CXCL8 (IL-8) 
B)  CXCL10 (IP-10) 
C)  CCL19 (EL
C)  
D)  CCL11 (Eotaxin) 
E)  CCR5F) CXCR1G) CX3CL1 (Fractalkine)

Question 12

For each of the descriptions of a biologic function in questions , select the T cell-derived cytokine (A-E) that matches it.
-Stimulates expression of class II MHC on various cell types

Accepted Answer

A)  Interferon-g
B)  Interleukin (IL) -4
C)  IL-5
D)  Transforming growth factor-b
E)  Lymphotoxin

Question 13

For each of the following descriptions of a chemokine or chemokine receptor, select the chemokine or chemokine receptor (A-G) that most closely matches it.
-Binds chemokines important in T cell recruitment into peripheral inflammatory sites

Accepted Answer

A)  CXCL8 (IL-8) 
B)  CXCL10 (IP-10) 
C)  CCL19 (EL
C)  
D)  CCL11 (Eotaxin) 
E)  CCR5F) CXCR1G) CX3CL1 (Fractalkine)

Question 14

Matching
The tumor necrosis factor (TNF) family of proteins includes several soluble and membrane proteins that share structural homologies.
 All members of this family bind to members of the TNF-receptor family of molecules expressed on cell surfaces.
TNF-R family members are structurally homologous to one another and utilize similar signal transduction pathways.
For each description of a TNF or a TNF-R family member in questions , select the term listed in options A-E that best matches it.
-Expressed as a membrane molecule on the surface of activated T cells, it binds to a receptor found on many cell types, including T cells, and induces apoptosis.

Accepted Answer

A)  TNF-RI
B)  CD40
C)  Fas ligand
D)  RANK
E)  Lymphotoxin

Exam 9: Cytokines

For each of the following descriptions of a chemokine or chemokine receptor, select the chemokine or chemokine receptor (A-G) that most closely matches it. -Important in dendritic cell and T cell localization in lymph nodes

For each of the descriptions of a biologic function in questions , select the T cell-derived cytokine (A-E) that matches it. -Inhibits proliferation and differentiation of T cells and the activation of macrophages

For each of the following descriptions of a chemokine or chemokine receptor, select the chemokine or chemokine receptor (A-G) that most closely matches it. -Mediates neutrophil recruitment into tissues

For each of the descriptions of a biologic function in questions , select the T cell-derived cytokine (A-E) that matches it. -Induces B cell isotype switching to IgE production

For each of the following descriptions of a chemokine or chemokine receptor, select the chemokine or chemokine receptor (A-G) that most closely matches it. -Important mediator of inflammatory component of immediate hypersensitivity reactions

For each of the descriptions of a biologic function in questions , select the T cell-derived cytokine (A-E) that matches it. -Stimulates growth and activation of eosinophils

For each of the following descriptions of a chemokine or chemokine receptor, select the chemokine or chemokine receptor (A-G) that most closely matches it. -Binds to interleukin-8

For each of the descriptions of a biologic function in questions , select the T cell-derived cytokine (A-E) that matches it. -Stimulates expression of class II MHC on various cell types

For each of the following descriptions of a chemokine or chemokine receptor, select the chemokine or chemokine receptor (A-G) that most closely matches it. -Binds chemokines important in T cell recruitment into peripheral inflammatory sites