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Phenytoin Is a Weakly Acidic Drug with a PKa of 8.3

Question 4

Multiple Choice

Phenytoin is a weakly acidic drug with a pKa of 8.3. Assume that the urine has a pH of 6.2. To what degree will phenytoin be ion trapped in the urine?


A) extensive ion trapping
B) moderate ion trapping
C) no ion trapping
D) insufficient data provided
E) none of the above

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