The Novel Basic Drug Methcathinone Has a PKa of 8

Multiple Choice

The novel basic drug methcathinone has a pKa of 8. OF is collected from a driver stopped for possible DUI and is tested in a forensic toxicology laboratory. Assuming the blood is at physiological pH and the OF has a pH of 6.5, the concentration detected in the OF is likely to be _________ than the plasma concentration.

A) less than
B) essentially the same
C) higher
D) much less
E) none of the above