Why Do Adenovirus Vaccine Vectors Have Limited Utility

Multiple Choice

Why do adenovirus vaccine vectors have limited utility?

A) Adenoviruses are small and cannot incorporate large numbers of genes from other viruses.
B) Most humans have preexisting antibodies that neutralize the vector before it can reach target tissue.
C) The immune response is weaker because the vector displays antigens from both the adenovirus and the pathogenic virus, diluting the immune response.
D) If the adenovirus incorporates large numbers of genes from pathogenic viruses, it may lose the ability to infect host tissue and elicit an immune response.