In the Nonpolar Environment of Most Enzyme Active Sites,which Statement

Multiple Choice

In the nonpolar environment of most enzyme active sites,which statement applies to charge-charge interactions between the enzyme and the substrate?

A) They are rare due to the non-polar environment.
B) They are frequent,but not very strong in the nonpolar environment.
C) They are stronger in the nonpolar environment.
D) The polarity of the active site has no effect on the strength of the charge-charge interactions.