Constitutive Activation of the Ras Protein Is Observed in Many

Multiple Choice

Constitutive activation of the Ras protein is observed in many cancers.Which type of abnormality in the Ras protein is most likely to cause cancer?

A) Mutation of the site that is normally phosphorylated by the MAP kinases.
B) Mutation of the site that is normally phosphorylated by protein kinase A.
C) Inability to hydrolyze bound guanosine triphosphate (GTP) .
D) Inability to bind GTP.
E) Inability to activate the protein kinase Raf.