A 43-Year-Old Man with a History of Kidney Transplantation Is $\beta$

Multiple Choice

A 43-year-old man with a history of kidney transplantation is on immunosuppressive drugs.He presents to the emergency department 84 days after transplantation with a slight fever,accompanied by violent shaking chills,rapid heart rate,and dangerously low blood pressure.Blood cultures are positive for gram-negative bacteria,including Klebsiella and Pseudomonas.Although the patient was initially alert and responsive to fluids and antibiotic therapy,his condition rapidly deteriorates into disseminated intravascular coagulation (DIC) ,hypoglycemia,and cardiovascular failure.Which of the following is an essential mediator of this patient's condition?

A) Transforming growth factor- $\beta$
B) Tumor necrosis factor- $\alpha$
C) Interleukin (IL) -2
D) IL-10
E) IL-3