A 3-Year-Old Boy,who Is Small for His Age,has a History

Multiple Choice

A 3-year-old boy,who is small for his age,has a history of pyogenic (pus-producing) infections and cutaneous skin abscesses.Physical examination is remarkable for high fever,enlarged liver and spleen,and swollen cervical lymph nodes.A culture from an abscess on his arm reveals Staphylococcus aureus,a gram-positive bacteria that is also catalase-positive.Immunoglobulin and complement levels are normal.Results of the nitroblue tetrazolium test are consistent with a diagnosis of chronic granulomatous disease (CGD) .The boy's immunodeficiency involves impaired generation of which of the following?

A) C5a
B) C-reactive protein
C) Mannose-binding lectin
D) Reactive oxygen intermediates
E) Membrane attack complex