LFA-1 Is an Integrin That Promotes T Cell Activation by Which

Multiple Choice

LFA-1 is an integrin that promotes T cell activation by which one of the following mechanisms?

A) Binds to the $\alpha$ 3 domain of class I MHC molecules,mediating high avidity between T cells and antigen-presenting cells (APCs)
B) Binds to B7-1 or B7-2 on the surface of APCs,mediating "signal 2"
C) Binds to GlyCAM-1 on high endothelial venules of lymph nodes,mediating rolling of T cells on endothelium
D) Binds to ICAM-1 on the surface of a variety of cells,mediating firm adhesion between T cells and APCs or endothelial cells
E) Binds to VCAM-1 on the surface of cytokine-activated endothelial cells,mediating homing of T cells to peripheral sites of inflammation