A 67 Year Old Man,who Had Been an Accounting Executive

Multiple Choice

A 67 year old man,who had been an accounting executive for a large manufacturing firm most of his career,began to have problems driving in his city.He frequently became lost.He was also having difficulties finding the proper word to describe simple things,like a fork,or a pair of pliers.A CT scan showed atrophy of cerebral cortex,and a relative increase in size of the lateral ventricles.He died of an apparent heart attack a few months after the onset of symptoms,and his wife requested an autopsy.Representative sections are shown in the accompanying photomicrographs.Which one of the following is the best diagnosis?

A) Alzheimer's disease
B) Meningitis
C) Parkinson's disease
D) Dementia with Lewy bodies
E) Creutzfeldt-Jakob disease