In the First Generation of Adenovirus Vectors the E3 Gene

Multiple Choice

In the first generation of adenovirus vectors the E3 gene was deleted.How could the virus replicate in the absence of the E3 gene products?

A) A plasmid containing the E3 gene is transfected along with the viral DNA.
B) The cell line that the recombinant viruses are grown in carries the E3 gene.
C) The E3 gene products are not required for adenovirus replication.
D) The transgene inserted into the virus complements for the E3 gene.
E) The E3 gene products are packaged into the virions.