DNA Protection Assays Identify Specific Nucleotide-Protein Contacts

Multiple Choice

DNA protection assays identify specific nucleotide-protein contacts. What is the role of deoxyribonuclease (DNase) I treatment in footprint analysis?

A) DNase I is used to break DNA previously bound to protein.
B) Protein-bound DNA is protected from DNase I and it can be isolated and characterized.
C) DNase I prepares protein-bound DNA for sequencing.
D) All of the above.
E) None of the above.