Evidence That Synaptotagmin Is the Ca²⁺ Sensor for Exocytosis of Neurotransmitters

Multiple Choice

Evidence that synaptotagmin is the Ca²⁺ sensor for exocytosis of neurotransmitters includes:

A) Ca²⁺ binding by synaptotagmin.
B) partial loss-of-function mutations of synaptotagmin in Drosophila and C.elegans that result in neurons that are defective in Ca²⁺-stimulated vesicle exocytosis.
C) uncoordinated embryonic muscle contractions in Drosophila and c.elegans mutants that lack synaptotagmin.
D) all of the above