How Are Open Reading Frames or Exons Predicted from Genomic

Multiple Choice

How are open reading frames or exons predicted from genomic sequence?

A) If the open reading frame is 10 amino acids long it is considered an exon.
B) If the sequence is absent in mRNA it is considered an exon.
C) If there is a splice donor and acceptor site at the ends of the open reading frame it is considered an exon.
D) If an open reading frame is 21 amino acids long or longer it is accepted as an exon.