Matthew Has the Inherited Form of the Eye Cancer Retinoblastoma

Multiple Choice

Matthew has the inherited form of the eye cancer retinoblastoma.His disease is caused by

A) a germinal mutation in one RB allele, and no mutation in the other allele.
B) a somatic mutation in each copy of the RB gene in the same cell.
C) a germinal mutation in one RB allele, then a somatic mutation in the other allele.
D) a somatic mutation in the one of the RB genes in the same area of the retina of one eye.
E) activation of the X-linked oncogene RB.