Question 1

__________ is a reversible process whereby platelets stick to a foreign surface.

Accepted Answer

A)  Aggregation 
B)  Adhesion 
C)  Reverse reaction 
D)  Agglutination 
E)  Secretion

Question 2

Plasminogen is activated to plasmin by all of the following except:

Accepted Answer

A)  TPA (tissue plasminogen activator) 
B)  Kallikrein 
C)  Calcium 
D)  Urokinase 
E)  Streptokinase

Question 3

Hageman factor corresponds to __________.

Accepted Answer

A)  Factor Xb, factor I 
B)  Factor II 
C)  Factor XII 
D)  None of the above

Question 4

What is the function of tissue thromboplastin in maintaining vascular integrity?

Accepted Answer

A)  Initiates fibrin formation through the extrinsic pathway of the coagulation system 
B)  Initiates fibrin formation through the intrinsic pathway of the coagulation system 
C)  Initiates fibrin lysis through the extrinsic pathway of the coagulation system 
D)  Initiates fibrin lysis through the intrinsic pathway of the coagulation system 
E)  None of the above

Question 5

The peripheral zone is a complex region of the platelet consisting of:

Accepted Answer

A)  Glycocalyx 
B)  Plasma membrane 
C)  Open canalicular system (OCS) 
D)  Submembranous region 
E)  All of the above

Question 6

Platelet stored products are released through the __________.

Accepted Answer

A)  Glycocalyx 
B)  Plasma membrane 
C)  OCS 
D)  Mitochondria 
E)  None of the above

Question 7

The final fibrin-split products are __________ and __________ fragments generated from one molecule of fibrinogen.

Accepted Answer

A)  X and Y 
B)  2D and 1E 
C)  Y and D 
D)  2X and 1D 
E)  E and 2Y

Question 8

Factor IX is involved with which clotting pathway?

Accepted Answer

A)  Intrinsic 
B)  Extrinsic 
C)  Common 
D)  A and B 
E)  All of the above

Question 9

With the exception of factor VIII, all the coagulation factors are produced in the __________.

Accepted Answer

A)  Bone marrow 
B)  Liver 
C)  Kidney 
D)  Spleen 
E)  None of the above

Question 10

Factor VIII is involved with which clotting pathway?

Accepted Answer

A)  Intrinsic 
B)  Extrinsic 
C)  Common 
D)  A and B 
E)  All of the above

Question 11

Which event activates the common pathway?

Accepted Answer

A)  Activation of factor X by factor VIIa, factor III, and calcium 
B)  Activation of factor X by IXa, factor VIII, calcium, and PF3 
C)  Activation of factor XII to XIIa 
D)  A and C 
E)  A and B

Question 12

The X monomer is the result of:

Accepted Answer

A)  Prothrombin splitting off pieces of the alpha and beta polypeptide from fibrinogen 
B)  Thrombin splitting off pieces of the alpha and beta polypeptide from fibrinogen 
C)  Plasmin splitting off pieces of the alpha and beta polypeptide and gamma polypeptide from fibrinogen 
D)  Plasmin splitting off pieces of the alpha and beta polypeptide and gamma polypeptide from fibrin 
E)  None of the above

Question 13

Factor I is involved with which clotting pathway?

Accepted Answer

A)  Intrinsic 
B)  Extrinsic 
C)  Common 
D)  A and B 
E)  All of the above

Question 14

The vascular system acts to prevent bleeding by which mechanism(s)?

Accepted Answer

A)  Vasoconstriction and reflex stimulation of adjacent vessels 
B)  Diversion of blood flow around damaged vasculature 
C)  Initiation of contact-activation of platelets with subsequent aggregation 
D)  Contact-activation of the coagulation system leading to fibrin formation 
E)  All of the above

Question 15

All of the following are characteristics of the fibrinogen group of coagulation proteins except:

Accepted Answer

A)  High-molecular-weight proteins. 
B)  Factors are not absorbed by BaSO4. 
C)  Factors are consumed during the coagulation process. 
D)  Factors V and VIII are the most stabile and therefore present in stored plasma. 
E)  Factors are increased during inflammation and pregnancy.

Question 16

Which of the following include specificities of plasma membrane receptors within the peripheral zone?

Accepted Answer

A)  ADP 
B)  Thrombin 
C)  Glycoprotein IIa 
D)  Serotonin 
E)  All of the above

Question 17

What role do membrane phospholipids play in the coagulation process?

Accepted Answer

A)  They are inhibitors of cyclo-oxygenase. 
B)  They are responsible for the synthesis of TXA2. 
C)  They provide a catalytic surface for the activation of various clotting factors. 
D)  They convert fibrinogen to fibrin. 
E)  None of the above

Question 18

The last stage involved in arresting bleeding after vessel damage is the formation of a __________.

Accepted Answer

A)  Fibrin degradation product 
B)  Stable platelet plug 
C)  Plasmin synthesizer 
D)  Vasodilator 
E)  None of the above

Question 19

What prostaglandin produced in the endothelium is a vasodilator and potent inhibitor of platelet aggregation?

Accepted Answer

A)  TXA2 
B)  PGG2 
C)  PGI2 
D)  PGH2 
E)  None of the above

Question 20

What is necessary for platelet aggregation?

Accepted Answer

A)  ADP 
B)  Fibrinogen 
C)  Calcium 
D)  All of the above 
E)  None of the above

Exam 24: Introduction to Hemostasis

__________ is a reversible process whereby platelets stick to a foreign surface.

Plasminogen is activated to plasmin by all of the following except:

Hageman factor corresponds to __________.

What is the function of tissue thromboplastin in maintaining vascular integrity?

The peripheral zone is a complex region of the platelet consisting of:

Platelet stored products are released through the __________.

The final fibrin-split products are and fragments generated from one molecule of fibrinogen.

Factor IX is involved with which clotting pathway?

With the exception of factor VIII, all the coagulation factors are produced in the __________.

Factor VIII is involved with which clotting pathway?

Which event activates the common pathway?

The X monomer is the result of:

Factor I is involved with which clotting pathway?

The vascular system acts to prevent bleeding by which mechanism(s) ?

All of the following are characteristics of the fibrinogen group of coagulation proteins except:

Which of the following include specificities of plasma membrane receptors within the peripheral zone?

What role do membrane phospholipids play in the coagulation process?

The last stage involved in arresting bleeding after vessel damage is the formation of a __________.

What prostaglandin produced in the endothelium is a vasodilator and potent inhibitor of platelet aggregation?

What is necessary for platelet aggregation?